|
KMID : 0369820150450060529
|
|
Jorunal of Korean Pharmaceutical Sciences
2015 Volume.45 No. 6 p.529 ~ p.539
|
|
|
Effects of absorbent materials on a self-emulsifying drug delivery system for a poorly water soluble drug
|
|
Park Jun-Bom
Choi Byoung-Kyu
Kang Chin-Yang
|
|
|
Abstract
|
|
|
|
In order to compare the effects of a solid carrier on the formulation of a solid self-microemulsifying drug delivery system (s-SMEDDS), a liquid SMEDDS was prepared with simvastatin. The SMEDDS was optimized using polyoxyl 35 castor oil [Kolliphor® EL] as a surfactant (S), diethylene glycol monoethylether [Transcutol® P] as a co-surfactant (C), and prophyleneglycol monocaprylate [Capryol 90] as the oil phase (O). The microemulsion area at the surfactant to co-surfactant ratio (1:1) was evaluated, and the SMEDDS at an S and C/O ratio of 7:3 was selected. Four types of adsorbents with high specific areas were used: Aerosil® 200, Sylysia® 350, Neusilin® US2, Neusilin® UFL2. SEM, DSC, and PXRD results revealed rough-surfaced particles that represent the amorphous state of s-SMEDDS. The optimized formulation with Neusilin® UFL2 markedly improved drug release. The present study concluded that s-SMEDDS was effectively formulated via adsorption with solid carriers.
|
|
|
KEYWORD
|
|
|
s-SMEDDS, Adsorption material, Solid carrier, Simvastatin, Drug release
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|